Use the known heritability of the hemophilia SNP to possibly correct a royal family lineage.
- Includes inquiry-based activities
- Historical background and relevance discussed
- Aligned to NGSS standards (HS-PS2-6, HS-PS2-5, HS-PS3-5, HS-PS4-2, HS-PS4-5, HS-LS1-1, HS-LS1-2, HS-LS1-6, HS-LS3-1, HS-LS3-2, HS-LS4-1, HS-LS4-2)
The heritability and genetic impact of the hemophilia Single nucleotide polymorphism (SNP) has been studied in medical and pharmaceutical industries since the early 1990's. With the information known about this special genetic marker, students will use PCR and gel electrophoresis to determine the potential relatedness of the royal Prince Leopold, who suffered from the disease, to a mystery woman claiming to be a long lost relative.
Note: This kit contains no human genomic DNA and the primers are not specific to the human genome.
Ordering information: Needed but not provided: thermal cycler, transilluminator, electrophoresis gel apparatus and power supply, 250 ml flasks, beakers, measuring cylinder, DI water, crushed ice, cooler, gloves, micropipette, tips.
Delivery information: Included in this kit: agarose tablets, microtubes, PCR strips, post-gel DNA stain, TAE buffer powder, weigh boats. A coupon is provided for perishable items: blue-light DNA dye, DNA ladder (100 bp), nuclease-free water, PCR master mix containing polymerase, primer mix, Prince Leopold DNA, and unknown female DNA.
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